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Ities have recommended that treatment be discontinued by tapering the SSRI (by gradually reducing the dose), symptoms have occurred despite tapering. Symptoms generally appear within a few days of discontinuing medication and persist for an average of 12 days (up to 21 days). They are relieved within 24 hours by re-administering the medication that was discontinued. It has been suggested that SSRIs may cause depression to worsen and even lead to suicide in a small number of patients. These potential side effects are difficult to evaluate in depressed patients because depression can progress with or without treatment, and suicide is itself a consequence of depression. Moreover, the evidence supporting these potential side effects is weak. Therefore, no conclusions can yet be drawn about the relationship between SSRIs and worsening depression and suicide. Until better information is available, patients receiving SSRIs should be monitored for worsening depression and suicidal tendencies. 1 Glossary paroxetine Center Next Printer-Friendly Format Email to a Friend From the Doctors at MedicineNet.com citalopram, Celexa - Defines the medication citalopram (Celexa) an antidepressant drug that affects neurotransmitters. Article includes descriptions, uses, drug interactions, and side effects. Source:MedicineNet Depression - Learn about depression symptoms, the types of depression, depressive disorder causes, and available treatments such as antidepressant medications, electroconvulsive therapy, and psychotherapies. Source:MedicineNet sertraline, Zoloft - Information on the medicatio

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