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Prozac. S, its long half life is also relevant because suddenly discontinuing SSRIs is known to produce both somatic and psychological withdrawal symptoms, a phenomenon known as "SSRI discontinuation syndrome". 16 It is generally accepted that fluoxetine´s withdrawal symptoms are much smoother than with other SSRIs, as the substance takes several days to completely leave the system. Fluoxetine is a potent CYP2D6 inhibitor, which can decrease metabolism of other medications. edit Formulations Fluoxetine is sold in capsules containing 10, 15, 20, 40, 60 or 90 mg of active ingredient, in tablets containing 10 mg, or 20 mg or in an oral suspension with concentration of 20 mg 5 ml. Prozac Weekly is 90 mg of regular enteric-coated fluoxetine, taken every 7 days. These capsules resist dissolution until reaching a segment of the gastrointestinal tract where the pH exceeds 5.5. The enteric coating delays the onset of absorption of fluoxetine 1 to 2 hours relative to the immediate-release formulations. prozac
 

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edit Controversy In the late 1990s, backlash grew against Prozac. Prozac's manufacturer, Eli Lilly and Company, which had earned billions from the drug's success became the target of numerous accusations (see David Healy affair). Lawsuits amounting to millions were instigated, contending that the drug made users feel suicidal and or caused other serious side effects. The accusations and lawsuits have been unsuccessful in stemming the prescription and use of the medication. Recently, the US FDA considered similar controversial issues regarding Prozac and its use in children and adolescents; it issued a "black box warning" (its most serious warning) for Prozac and other antidepressants (SSRI's and antidepressants of related classes) due to findings of increased suicidal tendency in some children and adolescents on the drugs. A more recent controversy embroiled Lilly, and a class action lawsuit has been filed after several people received in the mail free samples of Prozac Weeklyâ„¢. The prozac


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prozac embroiled Lilly prozac, and a class action lawsuit has been filed after several people received in the mail free samples of Prozac Weeklyâ„¢. The suit alleges that the samples' recipients' right to privacy was mishandled. Advertisements for Prozac have claimed for years that the medication works by correcting a chemical imbalance in the brain prozac, a claim that is not supported by the product label and has been confirmed as false by the head of the FDA psychopharmacological drugs committee. Yet these claims are likely to have led to the drug's popularity. 17 In August 2004 a report by the Environment Agency found trace amounts of fluoxetine in UK drinking water prozac, althou prozac.

prozac Gh the Drinking Water Inspectorate said that it was unlikely to pose a health risk. 18 However prozac, the effects from ingestion of fluoxetine in drinking water have not been investigated. In January prozac, 2005 prozac, the British Medical Journal leaked official Eli Lilly documents from the 1980s suggesting there was a link between fluoxetine and suicide and psychosis. It was originally claimed that the documents had not been previously disclosed prozac, and they were subsequently provided to the FDA for further investigation. However prozac, Eli Lilly insisted that the documents had been released in earlier litigation. 19 The British Medical Journal ultimately retracted its claim that the documents had not been previously disclosed prozac, and apologized to Eli Lilly. 20 Also in 2005 prozac, an internal document purportedly from Eli Lilly and Co. made public showed that the drug maker had data more than 15 years old showing that patients on its antidepressant Prozac were far more likely to attempt suicide and show hostility than were patients on other antidepressants and that the company attempted to minimize public awareness of the side effects. The 1988 document indicated that 3.7 percent of patients attempted suicide while on the blockbuster drug prozac, a rate more than 12 times that cited for any of four other commonly used antidepressants. The document prozac, whi.

prozac Documents had not been previously disclosed prozac, and apologized to Eli Lilly. 20 Also in 2005 prozac, an internal document purportedly from Eli Lilly and Co. made public showed that the drug maker had data more than 15 years old showing that patients on its antidepressant Prozac were far more likely to attempt suicide and show hostility than were patients on other antidepressants and that the company attempted to minimize public awareness of the side effects. The 1988 document indicated that 3.7 percent of patients attempted suicide while on the blockbuster drug prozac, a rate more than 12 times that cited for any of four other commonly used antidepressants. The document prozac, whic.

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Is approved for use in pediatric patients with MDD and obsessive compulsive disorder (OCD). (See WARNINGS and PRECAUTIONS, Pediatric Use.) Pooled analyses of short-term (4 to 16 weeks) placebo-controlled trials of 9 antidepressant drugs (SSRIs and others) in children and adolescents with major depressive disorder (MDD), obsessive compulsive disorder (OCD), or other psychiatric disorders (a total of 24 trials involving over 4400 patients) have revealed a greater risk of adverse events representing suicidal thinking or behavior (suicidality) during the first few months of treatment in those receiving antidepressants. The average risk of such events in patients receiving antidepressants was 4%, twice the placebo risk of 2%. No suicides occurred in these trials. Patient Information From eMedicine Health & 8226; Learn about Depression at eMedicineHealth.com From WebMD & 8226; Prozac is sometimes used to treat social anxiety disorder. Find additional health information on social anxiety disorder including other treatment options at WebMD.com. DESCRIPTION Prozac& 210; (fluoxetine hydrochloride) is a psychotropic drug for oral administration. It is also marketed for the treatment of premenstrual dysphoric disorder (Sarafem& 210; , fluoxetine hydrochloride). It is designated (& 177;)-N-methyl-3-phenyl-3- (a,a,a-trifluoro-p- tolyl)oxy propylamine hydrochloride and has the empirical formula of C17H18F3NO& 183;HCl. Its molecular weight is 345.79. The structural formula is: Fluoxetine hydrochloride is a white to off-white crystalline solid with a solubility of 14 mg mL in water. Each Pu

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