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tramadol 50mg G kg for approximately two years tramadol 50mg, although the study was not done with the Maximum Tolerated Dose). This finding is not believed to suggest risk in humans. No such finding occurred in a rate carcinogenicity study. No effects on fertility were observed for tramadol at oral dose levels up to 50 mg kg in male rats and 75 mg kg in female rats. Teratogenic Effects: Usage in Pregnancy Pregnancy Category C There are no adequate and well-controlled studies in pregnant women. Ultram should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Tramadol has been shown to be embryotoxic and fetotoxic in mice tramadol 50mg, rats and rabbits tramadol 50mg.
tramadol 50mg And maternally toxic doses 3 to 15 times the maximum human dose or higher (120 mg kg in mice tramadol 50mg, 25 mg kg or higher in rats and 75 mg kg or higher in rabbits) tramadol 50mg, but was not teratogenic at these dose levels. No harm to the fetus due to tramadol was seen at doses that were not maternally toxic. No drug-related teratogenic effects were observed in progeny of mice tramadol 50mg, rats or rabbits treated with tramadol by various routes (up to 140 mg kg for mice tramadol 50mg, 80 mg kg for rats or 300 mg kg for rabbits). Embryo and fetal toxicity consisted primarily of decreased fetal weights tramadol 50mg, skeletal ossification and increased supemumerary ribs at maternally toxic dose levels. Transient delays in developmental or behavioral parameters were also seen in pups in rat dams allowed to deliver. Embryo and fetal lethality were reported only in one rabbit study at 300 mg kg tramadol 50mg, a dose that would cause extreme maternal toxicity in the rabbit. In peri- and post-natal studies in rats tramadol 50mg, progeny of dams receiving oral (gavage) dose levels of 50 mg kg or greater had decreased weights tramadol 50mg, and pup survival was decreased early in lactation at 80 mg kg (6 to 10 times the maximum human dose). No toxicity was observed for progeny of dams receiving 8 tramadol 50mg, 10 tramadol 50mg, 20 tramadol 50mg, 25 or 40 mg kg. Maternal toxicity was observed at all dose levels tramadol 50mg, but effects on progeny were evident only at higher .
tramadol 50mg N developmental or behavioral parameters were also seen in pups in rat dams allowed to deliver. Embryo and fetal lethality were reported only in one rabbit study at 300 mg kg tramadol 50mg, a dose that would cause extreme maternal toxicity in the rabbit. In peri- and post-natal studies in rats tramadol 50mg, progeny of dams receiving oral (gavage) dose levels of 50 mg kg or greater had decreased weights tramadol 50mg, and pup survival was decreased early in lactation at 80 mg kg (6 to 10 times the maximum human dose). No toxicity was observed for progeny of dams receiving 8 tramadol 50mg, 10 tramadol 50mg, 20 tramadol 50mg, 25 or 40 mg kg. Maternal toxicity was observed at all dose levels tramadol 50mg, but effects on progeny were evident only at higher d.
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