ultram overdose Erstand the single-dose and 24-hour dose limit and the time interval between doses ultram overdose, since exceeding these recommendations can result in respiratory depression ultram overdose, seizures and death. Carcinogenesis ultram overdose, Mutagenesis ultram overdose, Impairment of Fertility A slight ultram overdose, but statistically significant ultram overdose, increase in two common murine tumors ultram overdose, pulmonary and hepatic ultram overdose, was observed in a mouse carcinogenicity study ultram overdose, particularly in aged mice. Mice were dosed orally up to 30 mg kg (90 mg m2 or 0.36 times the maximum daily human dosage of 246 mg m2) for approximately two years ultram overdose, although the study was not done with the Maximum Tolerated Dose. This finding is not believed to suggest risk in humans. ultram overdose.
ultram overdose No such finding occurred in a rat carcinogenicity study (dosing orally up to 30 mg kg ultram overdose, 180 mg m2 ultram overdose, or 0.73 times the maximum daily human dosage). Tramadol was not mutagenic in the following assays: Ames Salmonella microsomal activation test ultram overdose, CHO HPRT mammalian cell assay ultram overdose, mouse lymphoma assay (in the absence of metabolic activation) ultram overdose, dominant lethal mutation tests in mice ultram overdose, chromosome aberration test in Chinese hamsters ultram overdose, and bone marrow micronucleus tests in mice and Chinese hamsters. Weakly mutagenic results occurred in the presence of metabolic activation in the mouse lymphoma assay and micronucleus test in rats. Overall ultram overdose, the weight of evidence from these tests indicates that tramadol does not pose a genotoxic risk to humans. No effects on fertility were observed for tramadol at oral dose levels up to 50 mg kg (300 mg m2) in male rats and 75 mg kg (450 mg m2) in female rats. These dosages are 1.2 and 1.8 times the maximum daily human dosage of 246 mg m2 ultram overdose, respectively. Pregnancy ultram overdose, Teratogenic Effects: Pregnancy Category C Tramadol has been shown to be embryotoxic and fetotoxic in mice ultram overdose, (120 mg kg or 360 mg m2) ultram overdose, rats (³25 mg kg or 150 mg m2) and rabbits (³75 mg kg or 900 mg m2) at maternally toxic dosages ultram overdose, but was not teratogenic at these dose levels. These dosages on a mg m2 basis are 1.4 ultram overdose, ³0.6 ultram overdose, and ³3.6 times the maxim.
ultram overdose indicates that tramadol does not pose a genotoxic risk to humans. No effects on fertility were observed for tramadol at oral dose levels up to 50 mg kg (300 mg m2) in male rats and 75 mg kg (450 mg m2) in female rats. These dosages are 1.2 and 1.8 times the maximum daily human dosage of 246 mg m2 ultram overdose, respectively. Pregnancy ultram overdose, Teratogenic Effects: Pregnancy Category C Tramadol has been shown to be embryotoxic and fetotoxic in mice ultram overdose, (120 mg kg or 360 mg m2) ultram overdose, rats (³25 mg kg or 150 mg m2) and rabbits (³75 mg kg or 900 mg m2) at maternally toxic dosages ultram overdose, but was not teratogenic at these dose levels. These dosages on a mg m2 basis are 1.4 ultram overdose, ³0.6 ultram overdose, and ³3.6 times the maximu.
ultram overdose 
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