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Xanax tablet. 5 and 11 hours after the dosing. The pharmacokinetics of alprazolam and two of its major active metabolites (4-hydroxyal-prazolam and a-hydroxyalprazolam) are linear, and concentrations are proportional up to the recommended maximum daily dose of 10 mg given once daily. Multiple dose studies indicate that the metabolism and elimination of alprazolam are similar for theimmediate-release and the extended-release products. Food has a significant influence on the bioavailabil-ity of XANAX XR Tablets. A high-fat meal given up to 2 hours before dosing with XANAX XR Tablets increased the mean Cmax by about 25%.The effect of this meal on Tmax depended on the timing of the meal, with a reduction in Tmax by about 1 3 for subjects eating immediately before dosing and an increase in Tmax by about 1 3 for subjects eating 1hour or more after dosing. The extent of exposure (AUC) and elimination half-life (t1 2) were not affected by eating. There were significant differences in absorption rate for the xanax tablet

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XANAX XR Tablet, depending on the time of day administered, with the Cmax increased by 30% and the Tmax decreased by an hour following dosing at night, compared to morning dosing. Distribution The apparent volume of distribution of alprazolam is similar for XANAX XR and XANAX Tablets. In vitro, alprazolam is bound (80%) to human serum protein. Serum albumin accounts for the majority of the binding. Metabolism Alprazolam is extensively metabolized in humans, primarily by cytochrome P450 3A4 (CYP3A4),to two major metabolites in the plasma:4-hydroxyalprazo-lam and a-hydroxyalprazolam. A benzophenone derived from alprazolam is also found in humans. Their half-lives appear to be similar to that of alprazolam. The pharmacokinetic parameters at steady-state for the two hydroxylated metabolites of alprazolam (4-hydroxyalprazolam and a-hydroxy-alprazolam) were similar for XANAX and XANAX XR Tablets, indicating that the metabolism of alprazolam is not affected by absorption rate. The plasma con xanax tablet

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xanax tablet Following administration of XANAX XR Tablet ranges from 10.7-15.8 hours in healthy adults. Special Populations While pharmacokinetic studies have not been performed in special populations with XANAX XR Tablets xanax tablet, the factors (such as age xanax tablet, gender xanax tablet, hepatic or renal impairment) that would affect the pharmacokinetics of alprazolam after the administration of XANAX Tablets would not be expected to be different with the administration of XANAX XR Tablets. Changes in the absorption xanax tablet, distribution xanax tablet, metabolism xanax tablet, and excretion of benzodiazepines have been reported in a variety of disease states including alcoholism xanax tablet, impaired hepatic function xanax tablet, and impaired renal function. C xanax tablet.

xanax tablet Hanges have also been demonstrated in geriatric patients. A mean half-life of alprazolam of 16.3hours has been observed in healthy elderly subjects (range:9.0–26.9 hours xanax tablet, n=16) compared to 11.0hours (range:6.3–15.8 hours xanax tablet, n=16) in healthy adult subjects. In patients with alcoholic liver disease the half-life of alprazolam ranged between 5.8 and 65.3 hours (mean:19.7 hours xanax tablet, n=17) as compared to between 6.3 and 26.9 hours (mean=11.4 hours xanax tablet, n=17) in healthy subjects. In an obese group of subjects the half-life of alprazolam ranged between 9.9 and 40.4 hours (mean=21.8 hours xanax tablet, n=12) as compared to between 6.3 and 15.8 hours (mean=10.6 hours xanax tablet, n=12) in healthy subjects. Because of its similarity to other benzodiazepines xanax tablet, it is assumed that alprazolam undergoes transplacental passage and that it is excreted in human milk. Race—Maximal concentrations and half-life of alprazolam are approximately 15% and 25% higher in Asians compared to Caucasians. Pediatrics—The pharmacokinetics of alprazolam after administration of the XANAX XR Tablet in pediatric patients have not been studied. Gender—Gender has no effect on the pharmacokinetics of alprazolam. Cigarette Smoking—Alprazolam concentrations may be reduced by up to 50% in smokers compared to non-smokers. Drug-Drug Interactions Alprazolam is primarily eliminated by metabolism via .

xanax tablet Ecause of its similarity to other benzodiazepines xanax tablet, it is assumed that alprazolam undergoes transplacental passage and that it is excreted in human milk. Race—Maximal concentrations and half-life of alprazolam are approximately 15% and 25% higher in Asians compared to Caucasians. Pediatrics—The pharmacokinetics of alprazolam after administration of the XANAX XR Tablet in pediatric patients have not been studied. Gender—Gender has no effect on the pharmacokinetics of alprazolam. Cigarette Smoking—Alprazolam concentrations may be reduced by up to 50% in smokers compared to non-smokers. Drug-Drug Interactions Alprazolam is primarily eliminated by metabolism via c.

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