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Amine oxidase inhibitors - Cases of serious reactions, sometimes fatal, have been reported in patients receiving Zoloft in combination with a MAOI, including the selective MAOI, selegiline, and the reversible MAOI, moclobemide. Some cases presented with features resembling neuroleptic malignant syndrome. Similar cases, sometimes fatal, have been reported with other antidepressants during combined treatment with a MAOI and in patients who have recently discontinued an antidepressant or antiobsessional drug and have been started on a MAOI. Symptoms of a drug interaction between a SSRI and a MAOI include: hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital signs, mental status changes that include confusion, irritability, and extreme agitation progressing to delirium and coma. Therefore, Zoloft should not be used in combination with a MAOI or within 14 days of discontinuing treatment with a MAOI. Similarly, at least 14 days should elapse after discontinuing sertraline treatment and starting a MAOI. CNS depressants and alcohol - Co-administration of Zoloft (sertraline 200 mg daily) did not potentiate the effects of alcohol, carbamazepine, haloperidol or phenytoin on cognitive and psychomotor performance in healthy subjects. However the concomitant use of Zoloft and alcohol in depressed patients is not recommended. Interference with cognitive and motor performance - In controlled studies, Zoloft did not cause sedation and did not interfere with psychomotor performance. DOSAGE AND DIRECTIONS FOR USE ZOLOFT TABLETS should be given as
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