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Zoloft. Eak effects on norepinephrine and dopamine neuronal reuptake. At clinical doses, sertraline blocks the uptake of serotonin into human platelets. Like most clinically effective antidepressants, sertraline downregulates brain norepinephrine and serotonin receptors in animals. In receptor binding studies, sertraline has no significant affinity for adrenergic (alpha(1), alpha(2) and beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5-HT1A, 5-HT1B, 5-HT2) or benzodiazepine binding sites. In placebo-controlled studies in normal volunteers, sertraline did not cause sedation and did not interfere with psychomotor performance. Pharmacokinetics: Following multiple oral once-daily doses of 200 mg, the mean peak plasma concentration (C(max)) of sertraline is 0.19 mcg mL occurring between 6 to 8 hours post-dose. The area under the plasma concentration time is 2.8 mg hr L. For desmethylsertraline, C(max) is 0.14 mcg mL, the half-life 65 hours and the area under the curve 2.3 mg hr zoloft
 

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L. Following single or multiple oral once-daily doses of 50 to 400 mg day the average terminal elimination half-life is approximately 26 hours. Linear dose proportionality has been demonstrated over the clinical dose range of 50 to 200 mg day. Food appears to increase the bioavailability by about 40%: it is recommended that sertraline be administered with meals. Sertraline is extensively metabolized to N-desmethylsertraline, which shows negligible pharmacological activity. Both sertraline and N-desmethylsertraline undergo oxidative deamination and subsequent reduction, hydroxylation and glucuronide conjugation. Biliary excretion of metabolites is significant. Approximately 98% of sertraline is plasma protein bound. The interactions between sertraline and other highly protein bound drugs have not been fully evaluated (see Precautions). The pharmacokinetics of sertraline itself appear to be similar in young and elderly subjects. Plasma levels of N-desmethylsertraline show a 3-fold eleva zoloft


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zoloft Lushes 2.2 0.5 1.7 Fever 1.6 0.6 1.0 Back Pain 1.5 0.9 0.6 Metabolic and Nutritional Disorders Thirst 1.4 0.9 0.5 Musculo-Skeletal System Disorders Myalgia 1.7 1.5 0.2 Psychiatric Disorders Insomnia 16.4 8.8 7.6 Sexual Dysfunction- Male (1) 15.5 2.2 13.3 Somnolence 13.4 5.9 7.5 Agitation 5.6 4.0 1.6 Nervousness 3.4 1.9 1.5 Anxiety 2.6 1.3 1.3 Yawning 1.9 0.2 1.7 Sexual Dysfunction- Female (2) 1.7 0.2 1.5 Concentration Impaired 1.3 0.5 0.8 Reproduction Menstrual Disorder (2) 1.0 0.5 0.5 Respiratory System Disorders Rhinitis 2.0 1.5 0.5 Pharyngitis 1.2 0.9 0.3 pecial Senses Vision Abnormal 4.2 2.1 2.1 Tinnitus 1.4 1.1 0.3 Taste Perversion 1.2 0.7 0.5 Urinary S zoloft.

zoloft Ystem Disorders Micturition Frequency 2.0 1.2 0.8 Micturition Disorder 1.4 0.5 0.9 ----------------------------------------------------------------- *Events reported by at least 1% of patients treated with Zoloft are included. (1)% based on male patients only: 271 Zoloft and 271 placebo patients. Male sexual dysfunction can be broken down into the categories of decreased libido zoloft, impotence and ejaculatory delay. In this data set zoloft, the percentages of males in the Zoloft group with these complaints are 4.8% zoloft, 4.8% and 8.9% zoloft, respectively. It should be noted that since some Zoloft patients reported more than one category of male sexual dysfunction zoloft, the incidence of each category of male sexual dysfunction combined is larger than the incidence for the general category of male sexual dysfunction zoloft, in which each patient is counted only once. (2)% based on female patient only: 590 Zoloft and 582 placebo patients. ----------------------------------------------------------------- Other events observed during the premarketing evaluation of sertraline: During its premarketing assessment zoloft, multiple doses of sertraline were administered to 2710 subjects. The conditions and duration of exposure to sertraline varied greatly zoloft, and included (in overlapping categories) clinical pharmacology studies zoloft, open and double-blind studies zoloft, uncont.

zoloft Each category of male sexual dysfunction combined is larger than the incidence for the general category of male sexual dysfunction zoloft, in which each patient is counted only once. (2)% based on female patient only: 590 Zoloft and 582 placebo patients. ----------------------------------------------------------------- Other events observed during the premarketing evaluation of sertraline: During its premarketing assessment zoloft, multiple doses of sertraline were administered to 2710 subjects. The conditions and duration of exposure to sertraline varied greatly zoloft, and included (in overlapping categories) clinical pharmacology studies zoloft, open and double-blind studies zoloft, uncontr.

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